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A NOVEL METHOD FOR PREPARATION OF CARRAGEENAN/FISH SCALE COLLAGEN/ALLOPURINOL BIOCOMPOSITE FILM

Biopolymers such as carrapeenan or collagen can be used as carriers for loading a drug to enhance a drugs bioavailability. In this work, allopurinol was loaded on a carrageenan/collagen blend and the carrageenan/collagen/allopurinol (CCA) biocomposite ñlms were prepared using the ionic gelation method combined with the 3D printing method usìng carrageenan/collagen/allopurinol selasa 3D printing ink material. The advantages of the 3D printing method are the ease in shaping the design of films and the case ïncontrolling the thickness of films. The results of infrared ([R) spectroscopy and field emission scanning electron microscopy (FESEM) analyses showed that the CCA biocomposite fñlms have a regular structurc, and the Functional groups of conpponents in the biocomposites can interact with each other. After 30 minutes of immersion in distilled water and pH buffer solution, the biocomposite fñlÌms swelled and disintegrated. The carrageenan/collagen blend can control the release of allopurinol in simulated body fluids. ..

Từ khóa: A Novel Method for Preparation of Carrageenan, Fish Scale Collagen, Allopurinol Biocomposite Film

10 p hieutvdd 16/12/2021 97 0

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